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产品描述（Product Details）
| Assay Type | Sandwich-ELISA |
| Analyte | Soluble TROP-2 |
| Format | 96T |
| Reactivity | Human |
| Regulatory Status | RUO |
| Sensitivity | 46.875 pg/mL |
| Standard Curve Range | 46.875 pg/mL-12000 pg/mL |
| Assay Time | 1 hr 45 min |
| Suitable Sample Type | For the quantitative determination of human Soluble TROP-2 in Cell Culture Supernatants, Plasma, Serum. |
| Sample volume | 50 μL |
组分（Materials Provided）
| ID | Components | Size |
| CEA032-B01 | Pre-coated Anti-TROP-2 Antibody Microplate | 1 plate |
| CEA032-B02 | Human TROP-2 Standard | 20 μg ×2 |
| CEA032-B03 | Biotin-Anti-TROP-2 Antibody Con. Solution | 400 μL |
| CEA032-B04 | Biotin-Antibody Dilution Buffer | 8 mL |
| CEA032-B05 | Streptavidin-HRP Con. Solution | 0.5 mL |
| CEA032-B06 | Streptavidin-HRP Dilution Buffer | 15 mL |
| CEA032-B07 | 20× Washing Buffer | 50 mL |
| CEA032-B08 | Sample Dilution Buffer | 15 mL ×2 |
| CEA032-B09 | Substrate Solution | 12 mL |
| CEA032-B10 | Stop Solution | 6 mL |
背景（Background）
ClinMax? ELISA Kit is convenient ready-to-use immunoassay Kit, specifically designed to quantitate human TROP2 that is present in complex biological samples, such as human serum, plasma, and cell culture supernates.
A comprehensive validation of the ELISA method was performed following the ICH M10 on bioanalytical method validation and the FDA’s bioanalytical method validation guidance for industry. This validation included assessments of linearity, accuracy, precision, dilution linearity, recovery, and the hook effect. For details information, please refer to the DS.
ClinMax? ELISA Kits are manufactured in a GMP-certified facility and comply to the ISO 13485 standard, ensuring a high level of quality and reliability.
应用说明（Application）
The kit is developed for quantitative detection of human TROP2 in serum, plasma and cell culture supernates.
It is for research use only.
存储（Storage）
The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
原理（Assay Principles）
典型数据-Typical Data Please refer to DS document for The assay protocol.
For each experiment, each ELISA plate needs to set the standard curve. The minimum detectable concentration of CEA032-B02 is less than 46.875 pg/mL.
背景（Background）：TROP2
TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
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