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ACRO百普赛斯_logo Recombinant Proteins iso9001 ISO13485 CNAS
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HER2

点击查看靶点详细信息

  1. > 人表皮生长因子2(Human epidermal growth factor receptor 2，HER2)
  2. > 与乳腺癌, 胃癌, 肺癌，非小细胞肺癌相关
  3. > 可促进细胞分裂和蛋白水解酶的分泌，从而促进肿瘤侵袭和转移，在细胞分裂增殖和分化中起重要作用。
FAP

点击查看靶点详细信息

  1. > 成纤维细胞活化蛋白（Fibroblast activation protein，FAP）
  2. > 选择性高表达于癌相关成纤维细胞(CAF)表面
  3. > 可以降解肿瘤基质，在多种肿瘤中促进癌细胞浸润及转移。
实体瘤靶点蛋白
Mesothelin Glypican 3 Her2 ErbB3 FAP EGFRvIII EGF R GUCY2C PSMA B7-H3 (4Ig) FOLR1 VEGF R2 NKG2D Claudin-18.2 IL-13 R alpha 2 LILRB4 uPAR ROR1 PSCA Nectin-4 ROBO1 Mucin-1 NCAM-1 NRG1 Beta 1 更多靶点
验证数据
高纯度——MALS验证
Human Mesothelin高纯度经MALS验证
The purity of Human Mesothelin (296-580), His Tag, low endotoxin (Cat. No. MSN-H522a) is more than 90% and the molecular weight of this protein is around 32-47 kDa verified by SEC-MALS.
生物活性验证
>活性经ELISA验证，可用于早期抗体筛选等研究
GPC3 靶点蛋白高活性经ELISA验证
Immobilized Monoclonal Anti-Human GPC3 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Biotinylated Human Glypican 3, His,Avitag (Cat. No.GP3-H82E5) with a linear range of 0.2-3 ng/mL (QC tested).
Protocol
Her2 靶点蛋白高活性经ELISA验证
Immobilized Human Her2, His Tag (Cat. No. HE2-H5225) at 0.05 μg/mL (100 μL/well) can bind Trastuzumab with a linear range of 0.2-3 ng/mL (Routinely tested).

Protocol
>经FACS验证，适用于CAR阳性率质控和临床PK研究
Alexa Fluor 488-Labeled Human Mesothelin（Cat. No. MSN-HA2H9）
AF-488标记MSLN高活性 经FACS验证
5e5 of anti-MSLN CAR-293 cells were stained with 100 μL of 3 μg/mL of AF488-Labeled Human Mesothelin (296-580), His Tag (Cat. No. MSN-HA2H9) and negative control protein respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). AF488 signal was used to evaluate the binding activity (QC tested).
Protocol
APC-Labeled Human Her2 Protein（Cat. No. HE2-HA2H7）
APC标记Her2高活性 经FACS验证
5e5 of anti-Her2 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Her2, His Tag (Cat. No. HE2-HA2H7) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).
Protocol
PE-Labeled Human GPC3 Protein（Cat. No. GP3-HP2E3）
PE-标记 GPC3 高活性 经FACS验证
5e5 of anti-GPC3 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human Glypican 3, His Tag (Cat. No. GP3-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).
Protocol
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